Investigation of the Effects of Lipoic Acid and Dihydrolipoate on Experimental Renal Ischemia-Reperfusion Model

Objective: Ischemic/reperfusion (I/R) causes tissue injury and the leading cause of acute kidney injury. In this study, we aimed to investigate effects long short-term usage ALA DHLA on oxidative stress markers in experimental renal ischemia-reperfusion model. Methods: Forty male rats (250 300 gr) were divided into 5 groups: control; I/R group; long-term ALA+IR DHLA+IR group. Ischemia was carried out for 45 minutes followed by reperfusion 4 hours. Thiobarbituric acid reactive sunstances (TBARM), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activities samples serum total antioxidant status (TAS) (TOS) assayed spectrophotometrically. Tissue investigated histopathological analyzes. Results: TBARM (Control: 0.38±0.05. I/R: 1.37±0.17, ALA-treated group:1.025±0.15, group: 0.68±0.09, DHLA-treated 0.38±0.04 (nmol/mg protein); p<0,001) CAT 0.12±0.02, 0.04±0.008, 0.07±0.01, group:0.06±0.008, 0.08±0.01 (k/mg p<0.001), GSH-Px 0.45±0.04, 0.21±0.028, 0.37±0.05, group :0.34±0.05, 0.37±0.04 (U/mg OSI levels 1.32±0.15, 3.08±0.44, 1.775±0.21, 1.85±0.37, 1.53±0.21 (arbitrary unit) ; p<0.001) improved compared These findings more prominent Conclusion: We consider that both applications have potential treatment damage. Besides, is effective than ALA.